Direct Cell-to-Cell and Endocrine signaling

In direct cell to cell signaling, the cells are connected by gap junctions in animals and plasmodesmata in plants. The gap junctions are channeled through which many substances can travel easily between cells, and direct communication is established between cells. The signaling molecules are called intracellular mediators and are small molecules that are transmitted through gap junctions.

Endocrine signaling is one of the most common signaling methods in the body. In this type of communication, cells can transmit signals to other cells over long distances. Specialized cells secrete certain chemical messengers called hormones that are released into the bloodstream. These hormones travel in the blood and reach their target organ and start enacting their function. In human beings, the thyroid, pituitary gland, hypothalamus, gonads, and many other endocrine glands release hormones essential for the body to grow and sustain.

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An example of the endocrine hormone could be growth hormone (GH) produced by the pituitary gland. The GH promotes the growth of the muscles and cartilage of the body and helps the body grow. One of the GH’s critical functions is that it binds to the receptors of the cartilage and encourages them to divide.

Synaptic transmission is one of the basic types of paracrine signaling between the neurons of various nerves in the body. This transmission is named after the “synapse,” a junction formed between the neuronal axon terminals and dendritic cells. The neurons release selected chemicals called neurotransmitters such as acetylcholine, epinephrine, dopamine, etc. which communicates the message from one neuron to another. The neurotransmitters are published in the gap called synapse from one neuron, which is detected by the receptor of the other neuron. This type of neuronal signaling is called synaptic transmission. The neurons originate from the central nervous system structures such as the cerebral cortex, cerebellum, and brainstem and terminate in the effector organs. Few other neurons may arise from the skin surface and reach different parts of the CNS. The former neurons are the motor neurons, and the latter are sensory neurons.


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