Our body systems have their physiological value known as setpoints for various physiological parameters such as body temperature, blood pressure, and so on. When there is a fluctuation in the setpoints, the feedback loop is required to maintain homeostasis. Homeostasis is the process of maintenance of steady-state in our bodyâ€™s internal environment. These fluctuations are detected by receptors located in certain key places. The information about deviation from the set points is sent to the control centers in the brain. Thus control center paves a way to regulate the changes by initiating a negative feedback loop. The hypothalamus is the brain region known as the control center of the Homeostatic mechanism. It works together with the anterior and posterior pituitary glands closely to maintain homeostasis. The anterior lobe and a posterior lobe which is otherwise called anterior pituitary and posterior pituitary are responsible for regulating hormone levels which in turn maintains homeostasis.
Negative feedback loop is used in our body systems to maintain the physiological parameters in their normal optimal range. This feedback loop mechanism happens all the time in our body. The learning and understanding of this negative feedback loop helps in the basic understanding of our human physiology. The four basic components of feedback loop are defined as follows:
A stimulus: Stimulus is defined as anything that evokes response in an organism or in a tissue or cell of an organism. These responses are often variable and needs to be controlled. This also acts an indication stating our physiological parameters are not within the normal range with their set points.
A sensor: Sensors are also called as receptors. These are primary nerve ending in the skin surface or in the brain present to monitor the variability in both the internal and external environment of our body. Sensors are the receptors that receives the response and send those data to the control centers in our brain.
A control center: The role of control center is to receive the data from the sensor and to compare the data with the normal range of our body systems. If the particular physiological parameter is not within the normal range, these control centers send signal to the effectors.
An effector: An effector finally acts according to the signal received from control centers. An Effector generally initiates the feedback loop to maintain homeostasis. In alternate to the negative feedback loop mechanism, positive feedback loop intensifies the changes rather than reversing it. Thus, it is rare in our body mechanisms. In this case, changes are intensified till it reaches its end point. Birth of a child and blood clotting is example for positive feedback loop.
As defined previously, the control center present in the brain act as an integration center to receive signals from a sensor or receptor and exhibit an output response. This output response is sent to the effector to activate its feedback loop mechanism accordingly. The hypothalamus region of the brain is called the control center of the Homeostatic mechanism. This presents in the bottom middle of the human brain. It works with the anterior and posterior pituitary glands closely. The control center known as the hypothalamus controls functions in our body such as thirst, hunger, the temperature of our body, levels of water and salt, and energy levels. It plays a significant role in communicating with other organs of the body by releasing the hormone molecules. This relies on the two pituitary glands for doing this mechanism.
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